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Amidine derivatives, formed by substituting a guanidine amine with an R group, offer tuneable basicity (p K a 5 to 12) and consistent protonation at the imino nitrogen, with the TRX gemini surfactant outperforming Lipofectamine in transfection efficiency with lower cytotoxicity [98]

23 Age-related oxidative stress affects the nervous, endocrine, and immune systems and may create a vicious cycle involving chronic oxidative stress and inflammation, which support each other, and increase age-related morbidity and mortality

doi: 10.1038/s41575-022-00634-6 44 KimYJKimE-HHahmKB